BDBM50185987 2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2-yl)ethylidene)malononitrile::CHEMBL207649::US10906900, FDDNP::US9452985, FDDNP (reference for comparison)
SMILES [#6]-[#7](-[#6]-[#6]F)-c1ccc2cc(ccc2c1)-[#6](\[#6])=[#6](\C#N)C#N
InChI Key InChIKey=WPTZMSAPUZMSFV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50185987
Affinity DataIC50: 1.64E+3nMAssay Description:Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [1-42](Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 4.20nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
Affinity DataKd: 16.1nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKd: 34.9nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
Affinity DataKd: 16.1nMAssay Description:Table 6 & 7: Fresh solutions of each test compound (2.5 mM in DMSO) are diluted in PBS pH=7.4 at concentrations between 0.5 nM and 5 μM in the p...More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein [1-42](Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKi: 4.60nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
TargetIsoform Tau-F of Microtubule-associated protein tau(Human)
Centre National De La Recherche Scientifique
US Patent
Centre National De La Recherche Scientifique
US Patent
Affinity DataKi: 9.5nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Affinity DataKi: 25.1nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Affinity DataKi: 152nMAssay Description:Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uLMore data for this Ligand-Target Pair
Affinity DataKi: 172nMAssay Description:Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 256nM ΔG°: -8.99kcal/moleT: 2°CAssay Description:For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...More data for this Ligand-Target Pair
Affinity DataKi: >8.00E+3nMAssay Description:Displacement of [125I](E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)styrylbenzene from beta amyloid peptide in brain tissue at 50 uLMore data for this Ligand-Target Pair