BDBM50184857 CHEMBL203227::N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-methylbenzoyl)thiourea

SMILES COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4ccccc4C)cc3)c2cc1OC

InChI Key InChIKey=LQEFORQTPQKHOT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50184857   

TargetPlatelet-derived growth factor receptor alpha(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cell by transactivation enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-...)
Affinity DataIC50: 234nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cell by transactivation enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-...)
Affinity DataIC50: 434nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed