BDBM50182914 CHEMBL205652::N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrimidin-4-amine

SMILES Fc1cccc(COc2ccc(Nc3ccncn3)cc2Cl)c1

InChI Key InChIKey=SSNRTALFAXFKNE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50182914   

TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50182914(N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrimidin-...)
Affinity DataIC50: 320nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50182914(N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrimidin-...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50182914(N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrimidin-...)
Affinity DataIC50: 920nMAssay Description:Inhibition of EGFR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50182914(N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrimidin-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of HER2 by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed