BDBM50182401 CHEMBL3818261

SMILES CNc1ncc2cc(-c3ccc(cc3Cl)-n3ccc(C)cc3=O)c(=O)n(C[C@H]3CNCCO3)c2n1

InChI Key InChIKey=HBHSIBFSZDHHSC-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50182401   

TargetSerine/threonine-protein kinase PAK 1(Human)
Shanghai Chempartner

Curated by ChEMBL
LigandPNGBDBM50182401(CHEMBL3818261)
Affinity DataKi:  943nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged PAK1 kinase domain (249 to 545 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Shanghai Chempartner

Curated by ChEMBL
LigandPNGBDBM50182401(CHEMBL3818261)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of human recombinant PAK2 assessed as phosphorylation of coumarin labeled FRET peptide substrate at Ser/Thr19 preincubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed