BDBM50181894 CHEMBL378820::N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-4-((S)-3-morpholin-4-yl-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide

SMILES CC1(C)CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O

InChI Key InChIKey=NLJIRQSWGBPYHN-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50181894   

TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181894(N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-4-((S)-3...)
Affinity DataEC50:  9.31E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181894(N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-4-((S)-3...)
Affinity DataEC50:  4.20E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181894(N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-4-((S)-3...)
Affinity DataKi:  75nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181894(N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-4-((S)-3...)
Affinity DataKi:  732nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181894(N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-4-((S)-3...)
Affinity DataKi:  6.05E+3nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed