BDBM50181885 (R)-3-{4-[4-(4,4-dimethylpiperidin-1-yl)benzoylsulfamoyl]-2-nitrophenylamino}-N,N-dimethyl-4-phenylsulfanylbutyramide::CHEMBL379013

SMILES CN(C)C(=O)C[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(C)(C)CC1

InChI Key InChIKey=ITEIWMMRRYTVOC-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50181885   

TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181885((R)-3-{4-[4-(4,4-dimethylpiperidin-1-yl)benzoylsul...)
Affinity DataEC50:  1.50E+4nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181885((R)-3-{4-[4-(4,4-dimethylpiperidin-1-yl)benzoylsul...)
Affinity DataEC50:  2.14E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181885((R)-3-{4-[4-(4,4-dimethylpiperidin-1-yl)benzoylsul...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181885((R)-3-{4-[4-(4,4-dimethylpiperidin-1-yl)benzoylsul...)
Affinity DataKi:  75nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181885((R)-3-{4-[4-(4,4-dimethylpiperidin-1-yl)benzoylsul...)
Affinity DataKi:  1.79E+3nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed