BDBM50181882 (R)-3-(4-{[2'-methoxy-4'-(3-morpholin-4-ylpropyl)biphenyl-4-carbonyl]sulfamoyl}-2-nitrophenylamino)-N,N-dimethyl-4-phenylsulfanylbutyramide::CHEMBL383399

SMILES COc1cc(CCCN2CCOCC2)ccc1-c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@@H](CSc2ccccc2)CC(=O)N(C)C)c(c1)[N+]([O-])=O

InChI Key InChIKey=REHZPUBHLVXFPB-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50181882   

TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181882((R)-3-(4-{[2'-methoxy-4'-(3-morpholin-4-ylpropyl)b...)
Affinity DataEC50:  1.28E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181882((R)-3-(4-{[2'-methoxy-4'-(3-morpholin-4-ylpropyl)b...)
Affinity DataEC50:  7.63E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181882((R)-3-(4-{[2'-methoxy-4'-(3-morpholin-4-ylpropyl)b...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181882((R)-3-(4-{[2'-methoxy-4'-(3-morpholin-4-ylpropyl)b...)
Affinity DataKi:  121nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50181882((R)-3-(4-{[2'-methoxy-4'-(3-morpholin-4-ylpropyl)b...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed