BDBM50179871 CHEMBL383657::N-methyl-N-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)benzenesulfonamide

SMILES CN(c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1ccccc1

InChI Key InChIKey=QYKBEJIHKYFJQV-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50179871   

TargetOxysterols receptor LXR-beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50179871(N-methyl-N-(4-(1,1,1-trifluoro-2-hydroxypropan-2-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzenesulfonamide from GST-tagged LXRbeta ligand binding domai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50179871(N-methyl-N-(4-(1,1,1-trifluoro-2-hydroxypropan-2-y...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity against LXR alpha transiently transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179871(N-methyl-N-(4-(1,1,1-trifluoro-2-hydroxypropan-2-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 11beta-HSD1 using [3H]cortisone as substrate assessed as production of [3H]-cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed