BDBM50179852 2',4-difluoro-5'-(7-methyl-8-oxo-7,8-dihydroimidazo[1,2-d][1,2,4]triazin-3-yl)-1,1'-biphenyl-2-carbonitrile::CHEMBL205205

SMILES Cn1ncn2c(cnc2c1=O)-c1ccc(F)c(c1)-c1ccc(F)cc1C#N

InChI Key InChIKey=KCWCNDXYAPQOHU-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50179852   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179852(2',4-difluoro-5'-(7-methyl-8-oxo-7,8-dihydroimidaz...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABA-Aalpha5 receptor plus beta3gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179852(2',4-difluoro-5'-(7-methyl-8-oxo-7,8-dihydroimidaz...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABA-Aalpha3 receptor plus beta3gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179852(2',4-difluoro-5'-(7-methyl-8-oxo-7,8-dihydroimidaz...)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]Ro-151788 from human recombinant GABA-Aalpha1 receptor plus beta3gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed