BDBM50179657 (E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-methylpyridin-2-yl)urea::1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(3-methylpyridin-2-yl)urea::CHEMBL381820

SMILES Cc1cccnc1NC(=O)Nc1nc(O)cn1C

InChI Key InChIKey=ZDZQPVFMWLZHFJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50179657   

TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179657((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179657((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Affinity DataIC50: 320nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179657((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Affinity DataIC50: 681nMAssay Description:Antagonist activity at mGluR5 by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed