BDBM50178974 4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-indole-2-carboxylic acid::CHEMBL425939

SMILES CC(C)c1cc(Oc2c(Br)cc3[nH]c(cc3c2Br)C(O)=O)ccc1O

InChI Key InChIKey=PKPVFOLUOGCXPY-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50178974   

TargetThyroid hormone receptor beta(Human)
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178974(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human TR-beta-1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178974(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human TR-alpha-1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178974(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Affinity DataEC50:  4.20nMAssay Description:Efficacy against TRAF-beta-1 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178974(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Affinity DataEC50:  10nMAssay Description:Efficacy against TRAF-alpha-1 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178974(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Affinity DataIC50: 0.282nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178974(4,6-dibromo-5-(4-hydroxy-3-isopropylphenoxy)-1H-in...)
Affinity DataIC50: 2.51nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed