BDBM50178861 (1R,2R)-N1-methyl-N1-((2'-sulfamoylbiphenyl-4-yl)methyl)-N2-(4-(trifluoromethoxy)benzyl)cyclopentane-1,2-dicarboxamide::(1R,2R)-cyclopentane-1,2-dicarboxylic acid 1-[methyl-(2'-sulfamoyl-biphenyl-4-ylmethyl)-amide] 2-(4-trifluoromethoxy-benzylamide)::CHEMBL205412::trans-N1-methyl-N1-((2'-sulfamoylbiphenyl-4-yl)methyl)-N2-(4-(trifluoromethoxy)benzyl)cyclopentane-1,2-dicarboxamide::trans-cyclopentane-1,2-dicarboxylic acid 1-[methyl-(2'-sulfamoyl-biphenyl-4-ylmethyl)-amide] 2-(4-trifluoromethoxy-benzylamide)

SMILES CN(Cc1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(=O)[C@@H]1CCC[C@H]1C(=O)NCc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=KHYNGGVKOMNOKG-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50178861   

TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178861(trans-N1-methyl-N1-((2'-sulfamoylbiphenyl-4-yl)met...)
Affinity DataIC50: 830nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50178861(trans-N1-methyl-N1-((2'-sulfamoylbiphenyl-4-yl)met...)
Affinity DataKi:  180nMAssay Description:Binding affinity to Nav1.8 sodium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178861(trans-N1-methyl-N1-((2'-sulfamoylbiphenyl-4-yl)met...)
Affinity DataKi:  250nMAssay Description:Binding affinity to Nav1.7 sodium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178861(trans-N1-methyl-N1-((2'-sulfamoylbiphenyl-4-yl)met...)
Affinity DataKi:  290nMAssay Description:Inhibition of peripheral nerve sodium channel NaV1.7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed