BDBM50178767 2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide::CHEMBL112265

SMILES NC(=O)C1CCCc2c1[nH]c1ccccc21

InChI Key InChIKey=YMLOFDJHJSQCSN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50178767   

TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against pig brain NAD glycohydrolase (NADase) by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT3 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) assessed as deacetylation activity using acetylated p53 as substrate measured after 2 hrs by Fluor d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed