BDBM50178305 ARCHAZOLID A

SMILES C[C@H]1/C=C/C=C(/[C@H]([C@H]([C@@H](/C=C/C(=C\C(=C/[C@@H]([C@@H](/C=C(/C/C=C(/C(=O)O[C@@H]1c2csc(n2)[C@H](CC(C)C)OC(=O)NC)\C)\C)O)C)\C)/C)O)C)OC)\C

InChI Key InChIKey=CUYVVUGLFUIZAZ-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50178305   

TargetP2X purinoceptor 3(Human)
Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50178305(ARCHAZOLID A)
Affinity DataIC50: 86nMAssay Description:Inhibition of human P2X3 assessed as reduction in agonist-induced intracellular Ca2+ concentration pre-incubated for 30 mins before agonist addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50178305(ARCHAZOLID A)
Affinity DataEC50:  200nMAssay Description:Agonist activity at farnesoid x receptor(unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50178305(ARCHAZOLID A)
Affinity DataIC50: 352nMAssay Description:Inhibition of human leukocyte elastase assessed as reduction in pNA release using chromogenic MeO-Suc-Ala-Ala-Pro-Val-pNA substrate measured over 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50178305(ARCHAZOLID A)
Affinity DataKi:  967nMAssay Description:Displacement of [3H]PSB-11 from human A3 adenosine receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed