BDBM50178265 2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)-1-(4-fluorophenyl)-N-(phenylsulfonyl)-8-aza-bicyclo[3.2.1]octane-6-carboxamide::CHEMBL382720

SMILES Fc1ccc(cc1)C12CC(C(CCC1NCc1cc(OC(F)(F)F)ccc1OC1CC1)N2)C(=O)NS(=O)(=O)c1ccccc1

InChI Key InChIKey=XVOFQVYYIGNDLB-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50178265   

TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178265(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)...)
Affinity DataIC50: 0.270nMAssay Description:Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178265(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed