BDBM50178164 CHEMBL3815023::US10206931, Example 173

SMILES CC(c1ccccc1)n1cc(cn1)-c1cccc2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=BOYFTCVHQXVDDZ-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50178164   

TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178164(CHEMBL3815023 | US10206931, Example 173)
Affinity DataIC50: 1.60E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178164(CHEMBL3815023 | US10206931, Example 173)
Affinity DataIC50: 160nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178164(CHEMBL3815023 | US10206931, Example 173)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178164(CHEMBL3815023 | US10206931, Example 173)
Affinity DataIC50: 336nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM50178164(CHEMBL3815023 | US10206931, Example 173)
Affinity DataIC50: 1.21E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent