BDBM50177767 2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl)-5-(5-{2-[3-(3,4-dichloro-phenyl)-2-methoxycarbonyl-8-aza-bicyclo[3.2.1]oct-8-yl]-ethylcarbamoyl}-pentylsulfamoyl)-benzenesulfonic acid anion::CHEMBL196760

SMILES CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCN3C4CCC3[C@H]([C@H](C4)c3ccc(Cl)c(Cl)c3)C(=O)OC)c3ccc(cc3oc2c1)=[N+](CC)CC

InChI Key InChIKey=WYURUVQXJTWRLS-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50177767   

TargetSodium-dependent serotonin transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]CFT from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  20nMAssay Description:Inhibition of 2,5,6-[3H]-dopamine uptake at human DAT expressed in African green monkey COS7 cells incubated for 10 mins prior to radioligand additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  91nMAssay Description:Inhibition of 2,5,6-[3H]-dopamine uptake at human NET expressed in African green monkey COS7 cells incubated for 10 mins prior to radioligand additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  94nMAssay Description:Inhibition of 5-hydroxy[3H]tryptamine uptake at human SERT expressed in African green monkey COS7 cells incubated for 10 mins prior to radioligand ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  194nMAssay Description:Displacement of [3H]dopamine from human NET expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  392nMAssay Description:Displacement of [3H]5HT from human SERT expressed in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed