BDBM50176377 (R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamide::CHEMBL204449

SMILES C[C@@H](NC(=O)c1cccnc1Oc1ccc(F)cc1)c1cccs1

InChI Key InChIKey=LRQBXHMVEXEFBO-UHFFFAOYSA-N

Data  17 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50176377   

LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 107nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PDE9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PDE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 925nMAssay Description:Inhibition of release of TNF alpha in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PDE10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of PDE4CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 185nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PDE3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of C5a mediated human eosinophil chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAF mediated human eosinophil chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Eotaxin mediated by human eosinophil chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataEC50:  22nMAssay Description:cAMP elevation in U937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed