BDBM50176000 3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)-N-(2,4-difluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine::CHEMBL370808

SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12)C#CC(C)(C)N

InChI Key InChIKey=OAVQAUQHQJNYKR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50176000   

TargetHepatocyte growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176000(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory activity against c-MetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176000(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against murine p38-alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176000(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibitory activity against JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176000(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibitory activity against HER1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50176000(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed