BDBM50175944 8-((cis, rac)-2-hydroxy-2-p-tolyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL200257

SMILES Cc1ccc(cc1)[C@]1(O)CCCC[C@H]1N1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key InChIKey=LHOWPDRNDVSXJJ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50175944   

TargetSodium- and chloride-dependent glycine transporter 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175944(8-((cis, rac)-2-hydroxy-2-p-tolyl-cyclohexyl)-1-ph...)
Affinity DataEC50:  2.50E+4nMAssay Description:Displacement of [3H]glycine from human GlyT2 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175944(8-((cis, rac)-2-hydroxy-2-p-tolyl-cyclohexyl)-1-ph...)
Affinity DataEC50:  140nMAssay Description:Displacement of [3H]glycine from human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175944(8-((cis, rac)-2-hydroxy-2-p-tolyl-cyclohexyl)-1-ph...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity at human mu opioid receptor in BHK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175944(8-((cis, rac)-2-hydroxy-2-p-tolyl-cyclohexyl)-1-ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed