BDBM50175929 8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL203356

SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccccc2)CC1

InChI Key InChIKey=QMECPMOWMNRLSL-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50175929   

TargetSodium- and chloride-dependent glycine transporter 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50175929(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175929(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175929(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Affinity DataKi:  196nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175929(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175929(8-benzyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-o...)
Affinity DataKi:  2.95E+3nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed