BDBM50175689 (4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(dimethylamino)piperidin-1-yl)methanone::CHEMBL200229

SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(Nc2nccc(n2)-c2cc3ccccc3s2)cc1

InChI Key InChIKey=ALNKZWZEELZRCE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50175689   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated IkappaBalpha degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50: 300nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50: 80nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50: 400nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50: 400nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50: 752nMAssay Description:Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details Article
PubMed