BDBM50174917 5-chloro-N-(1-((7-methoxybenzo[d][1,3]dioxol-5-yl)methyl)piperidin-4-yl)-1H-indazol-3-amine::CHEMBL370222

SMILES COc1cc(CN2CCC(CC2)Nc2[nH]nc3ccc(Cl)cc23)cc2OCOc12

InChI Key InChIKey=XSUONKWZVREZIU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50174917   

TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50174917(5-chloro-N-(1-((7-methoxybenzo[d][1,3]dioxol-5-yl)...)
Affinity DataIC50: 280nMAssay Description:Binding affinity to human MCHr1 from neuronal IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50174917(5-chloro-N-(1-((7-methoxybenzo[d][1,3]dioxol-5-yl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Functional antagonism of MCH-mediated calcium release by FLIPR using human MCHr1 from neuronal IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50174917(5-chloro-N-(1-((7-methoxybenzo[d][1,3]dioxol-5-yl)...)
Affinity DataIC50: 280nMAssay Description:Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed