BDBM50174351 CHEMBL196707::[5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-acetic acid

SMILES Cc1c(CC(O)=O)c2cc(F)ccc2n1S(=O)(=O)c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=HKLGBZGYRPIFOH-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50174351   

TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50174351([5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-...)
Affinity DataIC50: 74nMAssay Description:Concentration required to inhibit PGD-2 induced change in the shape of human eosinophils expressing CRTH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50174351([5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-...)
Affinity DataIC50: 158nMAssay Description:Concentration required to inhibit PGD-2 (10 nM) stimulated [Ca2+] flux in CHO cells expressing human CRTH2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50174351([5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-...)
Affinity DataIC50: 67nMAssay Description:Concentration required to inhibit PGD-2 induced chemotaxis of Th2 cells expressing CRTH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50174351([5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-...)
Affinity DataIC50: 106nMAssay Description:Inhibition of CRTH2 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50174351([5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-...)
Affinity DataKi:  68nMAssay Description:Binding affinity towards human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50174351([5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-...)
Affinity DataKi:  68nMAssay Description:Antagonistic activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced calcium mobilization after 60 mins by Fluo-3 based fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50174351([5-Fluoro-1-(4-methanesulfonyl-benzenesulfonyl)-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards human DP receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed