BDBM50174331 CHEMBL3809832

SMILES COc1ccc(\C=C\C(=O)c2cccc(Nc3ncnc4cc(OC)c(OC)cc34)c2)cc1OC

InChI Key InChIKey=ROCWBTOPJAVZHR-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50174331   

TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50174331(CHEMBL3809832)Copy SMILESCopy InChI

Affinity DataIC50: 860nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells incubated for 30 mins measured up to 3600 secs with time intervals of 60 secs by calcein accumulation as...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/12/2017
Entry Details Article
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TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50174331(CHEMBL3809832)Copy SMILESCopy InChI

Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of human C-terminal GFP-tagged ABCG2 expressed in MDCK2 cells using pheophorbide A as substrate preincubated for 20 mins followed by subst...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/12/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL