BDBM50173833 6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenylamino)-1,7-naphthyridine-3-carbonitrile::CHEMBL199210

SMILES N#Cc1cnc2cnc(NCCN3CCOCC3)cc2c1Nc1ccc(Sc2ccccc2)cc1

InChI Key InChIKey=HIASHEATKNRFJC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50173833   

TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50: 960nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed