BDBM50173494 CHEMBL3810347::US11629146, Compound 108

SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc2nnc(n2n1)C(F)(F)F

InChI Key InChIKey=PHUZESTUSFSONE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50173494   

TargetSodium channel protein type 5 subunit alpha(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173494(CHEMBL3810347 | US11629146, Compound 108)
Affinity DataIC50: 223nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Praxis Precision Medicines

US Patent
LigandPNGBDBM50173494(CHEMBL3810347 | US11629146, Compound 108)
Affinity DataIC50: 8.00E+3nMAssay Description:CYP1A2 Inhibition in Human Liver Microsomes. Pooled human liver microsomes were incubated with individual CYP, CYP1A2, isozyme-specific marker substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
Go to US Patent