BDBM50173365 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID::5-Chloro-1-(4-chloro-benzyl)-3-phenylsulfanyl-1H-indole-2-carboxylic acid::CHEMBL370152

SMILES c1ccc(cc1)Sc2c3cc(ccc3n(c2C(=O)O)Cc4ccc(cc4)Cl)Cl

InChI Key InChIKey=VUPOTURDKDMIGQ-UHFFFAOYSA-N

Data  2 IC50  1 Kd  2 EC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50173365   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173365(5-Chloro-1-(4-chloro-benzyl)-3-phenylsulfanyl-1H-i...)
Affinity DataIC50: 26nMAssay Description:Inhibitory concentration against human peroxisome proliferator activated receptor gamma in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173365(5-Chloro-1-(4-chloro-benzyl)-3-phenylsulfanyl-1H-i...)
Affinity DataEC50:  55nMAssay Description:Effective agonist concentration for human PPAR gamma Gal4 construct in transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173365(5-Chloro-1-(4-chloro-benzyl)-3-phenylsulfanyl-1H-i...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory concentration against human peroxisome proliferator activated receptor alpha in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173365(5-Chloro-1-(4-chloro-benzyl)-3-phenylsulfanyl-1H-i...)
Affinity DataEC50:  57nMAssay Description:Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173365(5-Chloro-1-(4-chloro-benzyl)-3-phenylsulfanyl-1H-i...)
Affinity DataKd:  29nMAssay Description:Binding affinity to human PPARgamma (unknown origin) by competitive TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)