BDBM50172482 1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopropanecarboxylic acid::CHEMBL196945

SMILES OC(=O)C1(CC1)c1ccc(c(F)c1)-c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=LIYLTQQDABRNRX-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50172482   

TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50: 1.40E+4nMAssay Description:Concentration required to inhibit A beta 40 peptide 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50: 2.50E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50: 4.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50: 3.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant AKR1C2 transfected in Escherichia coli BL21 (DE3) pLysS competent cells using S-tetralol as substrate assessed as inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant AKR1C3 transfected in Escherichia coli BL21 (DE3) pLysS competent cells using S-tetralol as substrate assessed as inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed