BDBM50172470 2-(2-Fluoro-4'-trifluoromethyl-biphenyl-4-yl)-propionic acid::CHEMBL193971

SMILES CC(C(O)=O)c1ccc(c(F)c1)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=PAQRNRXJRSCEOL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50172470   

TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172470(2-(2-Fluoro-4'-trifluoromethyl-biphenyl-4-yl)-prop...)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172470(2-(2-Fluoro-4'-trifluoromethyl-biphenyl-4-yl)-prop...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant AKR1C2 transfected in Escherichia coli BL21 (DE3) pLysS competent cells using S-tetralol as substrate assessed as inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172470(2-(2-Fluoro-4'-trifluoromethyl-biphenyl-4-yl)-prop...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant AKR1C3 transfected in Escherichia coli BL21 (DE3) pLysS competent cells using S-tetralol as substrate assessed as inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed