BDBM50172467 1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-4-yl]-cyclopropanecarboxylic acid::CHEMBL372751

SMILES CC1(C)CCC(CC1)c1ccc(cc1)-c1ccc(cc1F)C1(CC1)C(O)=O

InChI Key InChIKey=CCTCISPYUXWOGO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50172467   

TargetCytochrome P450 2D6(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50: 5.30E+3nMAssay Description:Interaction with human cytochrome P450 isoform 2D6 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50: 8.40E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50: 1.01E+5nMAssay Description:Concentration required to inhibit A beta 40 peptide 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50: 1.70E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed