BDBM50172461 1-(2',2''-Difluoro-4-hydroxy-[1,1';4',1'']terphenyl-4''-yl)-cyclopropanecarboxylic acid::CHEMBL372846

SMILES OC(=O)C1(CC1)c1ccc(c(F)c1)-c1ccc(c(F)c1)-c1ccc(O)cc1

InChI Key InChIKey=PNSGYWXRFOWVFA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50172461   

TargetCytochrome P450 3A4(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172461(1-(2',2''-Difluoro-4-hydroxy-[1,1';4',1'']terpheny...)
Affinity DataIC50: 5.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172461(1-(2',2''-Difluoro-4-hydroxy-[1,1';4',1'']terpheny...)
Affinity DataIC50: 1.11E+5nMAssay Description:Concentration required to inhibit A beta 40 peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172461(1-(2',2''-Difluoro-4-hydroxy-[1,1';4',1'']terpheny...)
Affinity DataIC50: 7.40E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172461(1-(2',2''-Difluoro-4-hydroxy-[1,1';4',1'']terpheny...)
Affinity DataIC50: 3.36E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed