BDBM50172460 1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)-biphenyl-4-yl]-cyclopropanecarboxylic acid::CHEMBL197140

SMILES CC1(C)CC(CC(C)(C)C1)Oc1ccc(cc1)-c1ccc(cc1F)C1(CC1)C(O)=O

InChI Key InChIKey=NPPAGUSXMQPYGP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50172460   

TargetCytochrome P450 1A2(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50: 2.60E+4nMAssay Description:Interaction with human cytochrome P450 isoform 1A2 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50: 1.50E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50: 2.70E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50: 3.30E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50: 3.00E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2D6 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed