BDBM50172459 1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-yl)-cyclopropanecarboxylic acid::CHEMBL196947

SMILES OC(=O)C1(CC1)c1ccc(c(F)c1)-c1ccc(cc1)-c1ccc(O)cc1

InChI Key InChIKey=TUOLQOHKRDLKLU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50172459   

TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172459(1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50: 4.09E+5nMAssay Description:Concentration required to inhibit A beta 40 peptide 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172459(1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172459(1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50: 8.90E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172459(1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50: 2.15E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2D6 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172459(1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50: 3.50E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed