BDBM50172424 CHEMBL198361::N-(4-Methyl-2-morpholin-4-yl-quinolin-6-yl)-2-(4-trifluoromethoxy-phenoxy)-acetamide

SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCOCC1

InChI Key InChIKey=VTVKXJXECUDEMU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50172424   

TargetMelanin-concentrating hormone receptor 1(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172424(N-(4-Methyl-2-morpholin-4-yl-quinolin-6-yl)-2-(4-t...)
Affinity DataIC50: 82nMAssay Description:Displacement of 150p M [125I]MCH from human MCH1R expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 2(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172424(N-(4-Methyl-2-morpholin-4-yl-quinolin-6-yl)-2-(4-t...)
Affinity DataIC50: 10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172424(N-(4-Methyl-2-morpholin-4-yl-quinolin-6-yl)-2-(4-t...)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]myo-inositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172424(N-(4-Methyl-2-morpholin-4-yl-quinolin-6-yl)-2-(4-t...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172424(N-(4-Methyl-2-morpholin-4-yl-quinolin-6-yl)-2-(4-t...)
Affinity DataIC50: 1.60nMAssay Description:Displacement of 15 pM [125I]MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172424(N-(4-Methyl-2-morpholin-4-yl-quinolin-6-yl)-2-(4-t...)
Affinity DataIC50: 50nMAssay Description:Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by SPA binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed