BDBM50172191 3-[((4S,4aR)-6-Hydroxy-4a-methyl-1-(S)-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carbonyl)-amino]-adamantane-1-carboxylic acid ethyl ester::CHEMBL196335

SMILES CCOC(=O)C12CC3CC(CC(C3)(C1)NC(=O)[C@@]1(C)CCC[C@@]3(C)[C@H]1CCc1ccc(O)cc31)C2

InChI Key

Data  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50172191   

TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172191(3-[((4S,4aR)-6-Hydroxy-4a-methyl-1-(S)-methyl-1,2,...)
Affinity DataEC50:  830nMAssay Description:Effective concentration in transactivation assay using a chimeric LXR construct in HEK293 cells for LXRalpha receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172191(3-[((4S,4aR)-6-Hydroxy-4a-methyl-1-(S)-methyl-1,2,...)
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration in recombinant human LXRbeta ligand binding domain in homogeneous time-resolved fluorescence assay More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172191(3-[((4S,4aR)-6-Hydroxy-4a-methyl-1-(S)-methyl-1,2,...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration in LXRSPA alpha binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172191(3-[((4S,4aR)-6-Hydroxy-4a-methyl-1-(S)-methyl-1,2,...)
Affinity DataIC50: 530nMAssay Description:Inhibitory concentration in LXRSPA beta binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172191(3-[((4S,4aR)-6-Hydroxy-4a-methyl-1-(S)-methyl-1,2,...)
Affinity DataEC50:  760nMAssay Description:Effective concentration in transactivation assay using a chimeric LXR construct in HEK293 cells for LXRalpha receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed