BDBM50172079 CHEMBL3809489::US20250026773, Positive Drug 1 BGB324

SMILES Nc1nc(Nc2ccc3CC[C@@H](CCc3c2)N2CCCC2)nn1-c1cc2CCCc3ccccc3-c2nn1

InChI Key InChIKey=KXMZDGSRSGHMMK-UHFFFAOYSA-N

Data  34 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50172079   

TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant AXL incubated for 1 to 1.5 hrs by FRET based Z'-Lyte kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild-type human partial length KIT (I571 to D952 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 100nMAssay Description:Inhibition of wild-type human partial length AURKB (D25 to A303 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 530nMAssay Description:Inhibition of wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type human partial length MTOR (L1382 to W2549 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 37nMAssay Description:Inhibition of wild-type human partial length SRC (L240 to L536 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 20nMAssay Description:Inhibition of wild-type human partial length PDGFRA (V575 to D1002 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant AXL incubated for 1 to 1.5 hrs by FRET based Z'-Lyte kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 15nMAssay Description:Inhibition of wild-type human partial length MER (R557 to L884 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of AXL (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 14nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 14nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 650nMAssay Description:Inhibition of AXL (unknown origin) measured by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 2.25nMAssay Description:AXL enzyme (Carna, 08-107) configuration and addition: 33.33 ng/μL of AXL enzyme was diluted to 0.027 ng/μL (1.67×, final conc.=0.016 ng/μL) with 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human partial length FLT3 D835Y mutant (Q580 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant MER by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant TYRO3 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant AXL in human HeLa cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant AXL by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of wild-type human partial length MET (D1010 to S1367 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of wild-type human partial length AXL (R497 to Y821 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT (unknown origin) using poly [Glu, Try] 4:1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 8nMAssay Description:Inhibition of wild-type human partial length VEGFR2 (R787 to P1253 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant ABL by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human partial length FLT3 ITD mutant expressed in bacterial expression system using poly [Glu, Try] 4:1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 20nMAssay Description:Inhibition of wild-type human partial length DDR1 (R565 to V876 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 17nMAssay Description:Inhibition of wild-type human partial length TYRO3 (S497 to T814 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild-type human partial length RET (E713 to D1014 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human partial length Aurora A (E122 to K401 residues) expressed in mammalian expression system using poly [Glu, Try] 4:1 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed