BDBM50172077 CHEMBL3810063

SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)n1C

InChI Key InChIKey=RGAZVGZUBCFHRJ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50172077   

TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 500nMAssay Description:Inhibition of AXL (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant AXL expressed in Escherichia coli BL21 infected with T7 phage by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 48nMAssay Description:Inhibition of human recombinant MET expressed in Escherichia coli BL21 infected with T7 phage by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 48nMAssay Description:Inhibition of Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 48nMAssay Description:Inhibition of Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 10nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 10nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of GST-tagged AXL (unknown origin) (464 to 485 residues) using Axltide (CKKSRGDYMTMQJG-acid) peptide as substrate preincubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged Tyro3 (unknown origin) (453 to 890 residues) using Axltide (KKSRGDYMTMQIG-acid) peptide as substrate preincubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 63nMAssay Description:Inhibition of His6/TEV fused-GST-tagged Flt3 (unknown origin) (H564 to S993 residues) using Axltide (CKKSRGDYMTMQJ-acid) peptide as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed