BDBM50172075 CHEMBL3808844::US11053225, Positive control (LDC1267)

SMILES CCOc1cn(nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)-c1ccc(F)cc1C

InChI Key InChIKey=ISPBCAXOSOLFME-UHFFFAOYSA-N

Data  18 IC50  6 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50172075   

TargetTyrosine-protein kinase Fer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  107nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetCyclin-dependent kinase 8(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 3.18E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 338nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetTyrosine-protein kinase Lck(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 51nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetAurora kinase B(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 36nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 35nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase receptor UFO(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 29nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetTyrosine-protein kinase receptor TYRO3(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase Mer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 5nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  217nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase ABL1(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  154nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  124nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase receptor UFO(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 19nMAssay Description:Inhibition of AXL in human Hs578t cells by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/4/2017
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase receptor UFO(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  19nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetHepatocyte growth factor receptor(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  13nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase Mer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 68nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetTyrosine-protein kinase receptor UFO(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.90nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetTyrosine-protein kinase receptor TYRO3(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase Mer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 68nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase receptor UFO(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.90nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase receptor TYRO3(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase Mer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 68nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase receptor UFO(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.90nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase receptor TYRO3(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL