BDBM50171948 (2R,5R)-trans-Lobelane::(2R,6R)-1-Methyl-2,6-diphenethyl-piperidine::CHEMBL190870

SMILES CN1[C@@H](CCc2ccccc2)CCC[C@@H]1CCc1ccccc1

InChI Key InChIKey=ISVBJSRQEBWKPB-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50171948   

TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50171948((2R,5R)-trans-Lobelane | (2R,6R)-1-Methyl-2,6-diph...)
Affinity DataKi:  4.05E+3nMAssay Description:Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50171948((2R,5R)-trans-Lobelane | (2R,6R)-1-Methyl-2,6-diph...)
Affinity DataKi:  5.32E+3nMAssay Description:Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50171948((2R,5R)-trans-Lobelane | (2R,6R)-1-Methyl-2,6-diph...)
Affinity DataKi:  6.46E+3nMAssay Description:Inhibition of 5 nM [3H]DTBZ binding to Vesicular Monoamine Transporter (VAMT2) of rat vesicle membranes More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50171948((2R,5R)-trans-Lobelane | (2R,6R)-1-Methyl-2,6-diph...)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of 3 nM [3H]-MLA binding to Nicotinic acetylcholine receptor alpha7 of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed