BDBM50171815 4-[8-tert-Butyl-3-(4-chloro-phenyl)-2-oxo-1,3-diaza-spiro[4.5]dec-1-ylmethyl]-N-(2H-tetrazol-5-yl)-benzamide::CHEMBL380771

SMILES CC(C)(C)C1CCC2(CN(C(=O)N2Cc2ccc(cc2)C(=O)Nc2nnn[nH]2)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=WWOAFYMISUXXEG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50171815   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171815(4-[8-tert-Butyl-3-(4-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50: 116nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171815(4-[8-tert-Butyl-3-(4-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50: 446nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed