BDBM50171543 4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide::4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid hydroxyamide::CHEMBL382975

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)[N@@]2CCSC([C@@H]2C(=O)NO)(C)C

InChI Key InChIKey=CVZIHNYAZLXRRS-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50171543   

TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against matrix metallopeptidase 9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against matrix metallopeptidase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against TACE[ADAM metallopeptidase domain 17] in isolated enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against matrix metallopeptidase 13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 71nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against matrix metallopeptidase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against matrix metallopeptidase 13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against TACE[ADAM metallopeptidase domain 17] in isolated enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 201nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50171543(4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-t...)
Affinity DataIC50: 9nMAssay Description:Inhibition of TACE in human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)