BDBM50171224 CHEMBL196215::Cyclic sulfamide

SMILES FC(F)(F)CN1C[C@@]2(NS1(=O)=O)[C@H]1CC[C@@H]2Cc2cc(\C=C\CN3CCC(CC3)C(F)(F)F)ccc2C1

InChI Key InChIKey=NKHUILHBYOOZDF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50171224   

LigandPNGBDBM50171224(Cyclic sulfamide | CHEMBL196215)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171224(Cyclic sulfamide | CHEMBL196215)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed