BDBM50170766 CHEMBL189634::[(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyrido[1,2-c]pyrimidin-5-ylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2[C@H]1CC(=O)N(C2=O)c1ccccc1

InChI Key InChIKey=GJIMVDRKIKKNJY-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50170766   

TargetGastrin/cholecystokinin type B receptor(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 514nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I329F)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 36.6nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (S348A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (R336M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 35.2nMAssay Description:Inhibition of CCK-Induced inositol phosphate production in Cos-7 cells expressing human CCK1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 23.3nMAssay Description:Inhibition of CCK-induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (F107A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 71.6nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (T117A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 35.2nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (M195L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 33.2nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (S342A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 23nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (R197M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I352A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170766([(S)-1-((4aS,5R)-1,3-Dioxo-2-phenyl-octahydro-pyri...)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of CCK-induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I329A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed