BDBM50170764 CHEMBL366344::[(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-yl-1,3-dioxo-octahydro-pyrido[1,2-c]pyrimidin-5-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2[C@H]1CC(=O)N(C2=O)c1cccc2ccccc12

InChI Key InChIKey=ZILYTDLSNXITMI-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50170764   

TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 24.9nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (T117A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (S348A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 26.8nMAssay Description:Inhibition of CCK-induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (F107A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 582nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (R336M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of 71 pM [125I]BH-(Thr,Nle)CCK-9 binding to rat cholecystokinin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of 71 pM [125I]BH-(Thr,Nle)CCK-9 binding to rat cholecystokinin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 801nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I329F)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 227nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I352A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (R197M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of CCK-Induced inositol phosphate production in Cos-7 cells expressing human CCK1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (S342A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (M195L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50170764([(S)-2-(1H-Indol-3-yl)-1-((4aS,5R)-2-naphthalen-1-...)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of CCK-induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I329A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed