BDBM50168472 CHEMBL3805348::US9765060, Compound X

SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=YPMWYFVHFHAVSY-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50168472   

LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 1nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2017
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 1nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 77nMAssay Description:Inhibition of PI3Kbeta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 12nMAssay Description:Inhibition of PI3Kgamma (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 270nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 12nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 77nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 270nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 39nMAssay Description:Inhibition of PI3Kgamma in mouse RAW 264.7 cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in phosphorylation of AKT at 473 measured after 2 hr by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50: 21nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed