BDBM50168420 CHEMBL191594::[4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 1-methyl-piperidin-4-yl ester

SMILES CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OC4CCN(C)CC4)c(C(C)C)c23)c(F)cc1F

InChI Key InChIKey=NZBQAOCZTUIYGZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50168420   

TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168420([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 19nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168420([4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed