BDBM50167277 CHEMBL3797386

SMILES Fc1ccc2n(-c3cccnc3)c3cn[nH]c3c2c1

InChI Key InChIKey=BPCCTTNRJCTGHS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50167277   

TargetCytochrome P450 1A2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167277(CHEMBL3797386)
Affinity DataIC50: 126nMAssay Description:Inhibition of human CYP1A2 expressed in Escherichia coli DH5alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167277(CHEMBL3797386)
Affinity DataEC50:  100nMAssay Description:Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167277(CHEMBL3797386)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant full-length human MetAP2 catalytic domain (110 to 478 residues) expressed in baculovirus using Met-AMC as substrate by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed