BDBM50165915 CHEMBL3798986

SMILES COc1cc2ncnc(Nc3ccc4[nH]ncc4c3)c2cc1OC

InChI Key InChIKey=JWNOYNAROOUTEY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50165915   

TargetVascular endothelial growth factor receptor 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50165915(CHEMBL3798986)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant KDR (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50165915(CHEMBL3798986)
Affinity DataIC50: 600nMAssay Description:Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2017
Entry Details Article
PubMed
LigandPNGBDBM50165915(CHEMBL3798986)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by Ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2017
Entry Details Article
PubMed