BDBM50165652 (2-{4-[3-((E)-4-Bromo-phenyl)-acryloylamino]-3-fluoro-phenyl}-benzooxazol-5-yl)-acetic acid::2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid::CHEMBL196875::US11718609, Compound OGT_2115

SMILES OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2ccc(Br)cc2)c(F)c1

InChI Key InChIKey=LKBXWNYXDMSFQU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50165652   

TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165652(2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophen...)
Affinity DataIC50: 400nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165652(2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophen...)
Affinity DataIC50: 3.00E+4nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165652(2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophen...)
Affinity DataIC50: 3.00E+4nMAssay Description:In vitro inhibitory concentration against human Cytochrome P450 3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165652(2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophen...)
Affinity DataIC50: 398nMAssay Description:Inhibition of heparanaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165652(2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophen...)
Affinity DataIC50: 7.68E+3nMAssay Description:Recombinant human active heparanase derived from Chinese hamster ovary cells was from R&D Systems. Bovine serum albumin-coated 96 well microplates (9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent

TargetHeparanase(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50165652(2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophen...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human heparanase assessed as reduction in basic fibroblast growth factor binding incubated for 2 hrs by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed